Supramolecular Catalysis

Supramolecular Catalysis

When Non-Covalent Interactions Compete: How to Decode Entropy-Enthalpy Compensation

You spend six months designing a macrocyclic host that binds your substrate with a dissociation constant of 50 nanomolar. You run the catalytic assay....

Supramolecular Catalysis

Choosing a Supramolecular Scaffold Without a Crystal Structure: What NMR Tells You

You have a supramolecular catalyst that works—turns over substrate, shows rate acceleration, maybe even enantioselectivity. But the crystal structure?...

Supramolecular Catalysis

When Host-Guest Binding Doesn't Predict Catalytic Rate: Three Kinetic Traps

You spent weeks designing a supramolecular host. bindion is tight — dissociation constant in the low micromolar. Yet the catalytic rate is mediocre. W...